Funded through NIH/NIA:
Genetic variant-based drug discovery targeting conserved pathways of aging
U19 (Vijg/Robbins); Roles: PI Project 3 and Co-PI Administrative Core
The overall goal of this grant is to use genomic data from centenarians to identify pathways associated with longevity and to develop novel drugs targeting these pathways.
SIRT6 as a potential therapeutic target for treatment of Alzheimer’s Disease
U19 (Vijg/Robbins); Role: PI
The goal of this supplement is to determine if sequence variants, genes and pathways altered in centenarians protect against progression of Alzheimer’s disease pathology using murine models of AD.
Altered IGF-1R as a potential therapeutic target for treatment of Alzheimer’s disease
U19 (Vijg/Robbins); Niedernhofer, PI; Role: Co-I
The goal of this supplement is to determine if sequence variants, genes and pathways altered in centenarians protect against progression of Alzheimer’s disease pathology using murine models of AD.
Immune cells as a driver of cell non-autonomous aging
R01 (Niedernhofer); Role: Co-I
The goal of this project is to define the role of aged immune cells in driving aging through cell non-autonomous mechanisms.
Using the senolytic fisetin to suppress mortality in aged mice acutely exposed to murine beta-coronavirus
R01 (Niedernhofer); Role: Co-investigator
The goal of this project is to determine if senescent cells play a causal role in adverse outcomes in the elderly exposed to COVID-19.
Targeting cellular senescence to extend health span
P01 (Khosla, The Mayo Clinic); Role: PI, Core B
The overall goal of this multi-disciplinary, multi-site application is to build a firm foundation of discovery science in cellular senescence that leads to a pipeline of therapeutic strategies that slow or prevent age-associated diseases. The goal of Core B is to develop assays to identify small molecules that selectively kill senescent cells in relevant cell types (osteocytes, endothelium, adipocytes, etc.) and to conduct drug screens.
Inflammation, lipid metabolism and senescence
R01 (Bernlohr); Role: Co-I
The goal of this project is to define the role of MUFAs and reactive lipid aldehydes in regulating senescence and aging.
Funded through the Michael J. Fox Foundation for Parkinson’s Research:
Senescence in Parkinson’s disease and related disorders
ASAP (Lee) Niedernhofer, PI, Project 1; Role: Co-I Project 1
The goal of this project to determine if cellular senescence plays a role in driving Parkinson’s pathology, which cell types in the CNS senescence, and if senolytic drugs are therefore a novel approach to treat PD.
Funded through Unicyte:
Optimization of HLSC and serum derived EVs for reduction of senescence and extension of healthspan
SRA; Role: PI
The goal of this project is to optimize the ability of human liver stem cell derived EVs for suppression of senescence.