2023
Saavedra D, Añé-Kourí AL, Barzilai N, Caruso C, Cho KH, Fontana L, Franceschi C, Frasca D, Ledón N, Niedernhofer LJ, Pereira K, Robbins PD, Silva A, Suarez GM, Berghe WV, von Zglinicki T, Pawelec G, Lage A. Aging and chronic inflammation: highlights from a multidisciplinary workshop. Immun Ageing. 2023 Jun 8;20(1):25. doi: 10.1186/s12979-023-00352-w. PMID: 37291596; PMCID: PMC10248980.
Yousefzadeh MJ, Huerta Guevara AP, Postmus AC, Flores RR, Sano T, Jurdzinski A, Angelini L, McGowan SJ, O'Kelly RD, Wade EA, Gonzalez-Espada LV, Henessy-Wack D, Howard S, Rozgaja TA, Trussoni CE, LaRusso NF, Eggen BJL, Jonker JW, Robbins PD, Niedernhofer LJ, Kruit JK. Failure to repair endogenous DNA damage in β-cells causes adult-onset diabetes in mice. Aging Biol. 2023;1(1):20230015. doi: 10.59368/agingbio.20230015. Epub 2023 Oct 23. PMID: 38124711; PMCID: PMC10732477.
Zhang L, Pitcher LE, Prahalad V, Niedernhofer LJ, Robbins PD. Targeting cellular senescence with senotherapeutics: senolytics and senomorphics. FEBS J. 2023 Mar;290(5):1362-1383. doi: 10.1111/febs.16350. Epub 2022 Feb 1. PMID: 35015337.
Harrison DE, Strong R, Reifsnyder P, Rosenthal N, Korstanje R, Fernandez E, Flurkey K, Ginsburg BC, Murrell MD, Javors MA, Lopez-Cruzan M, Nelson JF, Willcox BJ, Allsopp R, Watumull DM, Watumull DG, Cortopassi G, Kirkland JL, Tchkonia T, Choi YG, Yousefzadeh MJ, Robbins PD, Mitchell JR, Acar M, Sarnoski EA, Bene MR, Salmon A, Kumar N, Miller RA. Astaxanthin and meclizine extend lifespan in UM-HET3 male mice; fisetin, SG1002 (hydrogen sulfide donor), dimethyl fumarate, mycophenolic acid, and 4-phenylbutyrate do not significantly affect lifespan in either sex at the doses and schedules used. Geroscience. 2023 Dec 2. doi: 10.1007/s11357-023-01011-0. Epub ahead of print. PMID: 38041783.
Englund DA, Jolliffe AM, Hanson GJ, Aversa Z, Zhang X, Jiang X, White TA, Zhang L, Monroe DG, Robbins PD, Niedernhofer LJ, Kamenecka TM, Khosla S, LeBrasseur NK. Senotherapeutic drug treatment ameliorates chemotherapy-induced cachexia. JCI Insight. 2023 Dec 5:e169512. doi: 10.1172/jci.insight.169512. Epub ahead of print. PMID: 38051584.
Henpita C, Vyas R, Healy CL, Kieu TL, Gurkar AU, Yousefzadeh MJ, Cui Y, Lu A, Angelini LA, O'Kelly RD, McGowan SJ, Chandrasekhar S, Vanderpool RR, Hennessy-Wack D, Ross MA, Bachman TN, McTiernan C, Pillai SPS, Ladiges W, Lavasani M, Huard J, Beer-Stolz D, St Croix CM, Watkins SC, Robbins PD, Mora AL, Kelley EE, Wang Y, O'Connell TD, Niedernhofer LJ. Loss of DNA repair mechanisms in cardiac myocytes induce dilated cardiomyopathy. Aging Cell. 2023 Apr;22(4):e13782. doi: 10.1111/acel.13782. Epub 2023 Feb 3. PMID: 36734200; PMCID: PMC10086531
Noureddine S, Nie J, Schneider A, Menon V, Fliesen Z, Dhahbi J, Victoria B, Oyer J, Robles-Carrillo L, Nunes ADC, Ashiqueali S, Janusz A, Copik A, Robbins PD, Musi N, Masternak MM. microRNA-449a reduces growth hormone-stimulated senescent cell burden through PI3K-mTOR signaling. Proc Natl Acad Sci U S A. 2023 Apr 4;120(14):e2213207120. doi: 10.1073/pnas.2213207120. Epub 2023 Mar 28. PMID: 36976763; PMCID: PMC10083567.
Toh WS, Yarani R, El Andaloussi S, Cho BS, Choi C, Corteling R, De Fougerolles A, Gimona M, Herz J, Khoury M, Robbins PD, Williams D, Weiss DJ, Rohde E, Giebel B, Lim SK. A report on the International Society for Cell & Gene Therapy 2022 Scientific Signature Series, "Therapeutic advances with native and engineered human extracellular vesicles". Cytotherapy. 2023 Mar 15:S1465-3249(23)00060-9. doi: 10.1016/j.jcyt.2023.02.009. Epub ahead of print. PMID: 36931996.
Samakkarnthai P, Saul D, Zhang L, Aversa Z, Doolittle ML, Sfeir JG, Kaur J, Atkinson EJ, Edwards JR, Russell RGG, Pignolo RJ, Kirkland JL, Tchkonia T, Niedernhofer LJ, Monroe DG, LeBrasseur NK, Farr JN, Robbins PD, Khosla S. In vitro and in vivo effects of zoledronate on senescence-associated secretory phenotype markers. bioRxiv. 2023 Feb 24:2023.02.23.529777. doi: 10.1101/2023.02.23.529777. Preprint.PMID: 36865244 Free PMC article.
Farr, J. N., Saul, D., Doolittle, M. L., Kaur, J., Rowsey, J. L., Vos, S. J., Froemming, M. N., Lagnado, A. B, Zhu, Y., Ikeno, J. I., Pignolo, R. J., Niedernhofer, L. J., Robbins, P. D., Jurk, D., Passos, J. F., LeBrasseur, N. K., Tchkonia, T., Kirkland, J. L., Monroe, D. G. and Khosla, S. Local senolysis in old mice only partially replicates the benefits of systemic senolysis. J Clin Invest. 2023 Feb 21:e162519. doi: 10.1172/JCI162519. Online ahead of print.PMID: 36809340
Evans CH, Ghivizzani SC, Robbins PD. Osteoarthritis gene therapy in 2022. Curr Opin Rheumatol. 2023 Jan 1;35(1):37-43. doi: 10.1097/BOR.0000000000000918. Epub 2022 Nov 9. PMID: 36508307; PMCID: PMC9757842.
2022
Narasimhan A, Flores RR, Camell CD, Bernlohr DA, Robbins PD, Niedernhofer LJ. Cellular Senescence in Obesity and Associated Complications: a New Therapeutic Target. Curr Diab Rep. 2022 Nov;22(11):537-548. doi: 10.1007/s11892-022-01493-w. Epub 2022 Oct 14. PMID: 36239841.
Simon M, Yang J, Gigas J, Earley EJ, Hillpot E, Zhang L, Zagorulya M, Tombline G, Gilbert M, Yuen SL, Pope A, Van Meter M, Emmrich S, Firsanov D, Athreya A, Biashad SA, Han J, Ryu S, Tare A, Zhu Y, Hudgins A, Atzmon G, Barzilai N, Wolfe A, Moody K, Garcia BA, Thomas DD, Robbins PD, Vijg J, Seluanov A, Suh Y, Gorbunova V. A rare human centenarian variant of SIRT6 enhances genome stability and interaction with Lamin A. EMBO J. 2022 Nov 2;41(21):e110393. doi: 10.15252/embj.2021110393. Epub 2022 Oct 10. PMID: 36215696; PMCID: PMC9627671.
Liu L, Yue X, Sun Z, Hambright WS, Wei J, Li Y, Matre P, Cui Y, Wang Z, Rodney G, Huard J, Robbins PD, Mu X. Reduction of senescent fibro-adipogenic progenitors in progeria-aged muscle by senolytics rescues the function of muscle stem cells. J Cachexia Sarcopenia Muscle. 2022 Oct 11. doi: 10.1002/jcsm.13101. Epub ahead of print. PMID: 36218080.
Schmitt CA, Tchkonia T, Niedernhofer LJ, Robbins PD, Kirkland JL, Lee S. COVID-19 and cellular senescence. Nat Rev Immunol. 2022 Oct 5:1–13. doi: 10.1038/s41577-022-00785-2. Epub ahead of print. PMID: 36198912; PMCID: PMC9533263.
Thompson EL, Pitcher LE, Niedernhofer LJ, Robbins PD. Targeting Cellular Senescence with Senotherapeutics: Development of New Approaches for Skin Care. Plast Reconstr Surg. 2022 Oct 1;150:12S-19S. doi: 10.1097/PRS.0000000000009668. Epub 2021 Sep 28. PMID: 36170431; PMCID: PMC9529240..
Saul D, Kosinsky RL, Atkinson EJ, Doolittle ML, Zhang X, LeBrasseur NK, Pignolo RJ, Robbins PD, Niedernhofer LJ, Ikeno Y, Jurk D, Passos JF, Hickson LJ, Xue A, Monroe DG, Tchkonia T, Kirkland JL, Farr JN, Khosla S. A new gene set identifies senescent cells and predicts senescence-associated pathways across tissues. Nat Commun. 2022 Aug 16;13(1):4827. doi: 10.1038/s41467-022-32552-1. PMID: 35974106; PMCID: PMC9381717.
Zhang L, Pitcher LE, Yousefzadeh MJ, Niedernhofer LJ, Robbins PD, Zhu Y. Cellular senescence: a key therapeutic target in aging and diseases. J Clin Invest. 2022 Aug 1;132(15):e158450. doi: 10.1172/JCI158450. PMID: 35912854; PMCID: PMC9337830.
Lee KA, Flores RR, Jang IH, Saathoff A, Robbins PD. Immune Senescence, Immunosenescence and Aging. Front Aging. 2022 May 30;3:900028. doi: 10.3389/fragi.2022.900028. PMID: 35821850; PMCID: PMC9261375.
Yousefzadeh MJ, Robbins PD, Huffman DM. Heterochronic parabiosis: a valuable tool to investigate cellular senescence and other hallmarks of aging. Aging (Albany NY). 2022 Apr 13;14(7):3325-3328. doi: 10.18632/aging.204015. Epub 2022 Apr 13. PMID: 35417855; PMCID: PMC9037264.
Chandra A, Lagnado AB, Farr JN, Doolittle M, Tchkonia T, Kirkland JL, LeBrasseur NK, Robbins PD, Niedernhofer LJ, Ikeno Y, Passos JF, Monroe DG, Pignolo RJ, Khosla S. Targeted clearance of p21- but not p16-positive senescent cells prevents radiation-induced osteoporosis and increased marrow adiposity. Aging Cell. 2022 Apr 1:e13602. doi: 10.1111/acel.13602. Epub ahead of print. PMID: 35363946.
Masters MC, Landay AL, Robbins PD, Tchkonia T, Kirkland JL, Kuchel GA, Niedernhofer LJ, Palella FJ. Chronic HIV Infection and Aging: Application of a Geroscience-Guided Approach. J Acquir Immune Defic Syndr. 2022 Feb 1;89(Suppl 1):S34-S46. doi: 10.1097/QAI.0000000000002858. PMID: 35015744; PMCID: PMC8751288.
Nunes ADC, Weigl M, Schneider A, Noureddine S, Yu L, Lahde C, Saccon TD, Mitra K, Beltran E, Grillari J, Kirkland JL, Tchkonia T, Robbins PD, Masternak MM. miR-146a-5p modulates cellular senescence and apoptosis in visceral adipose tissue of long-lived Ames dwarf mice and in cultured pre-adipocytes. Geroscience. 2022 Feb;44(1):503-518. doi: 10.1007/s11357-021-00490-3. Epub 2021 Nov 25. PMID: 34825304; PMCID: PMC8811002.
Zhang L, Pitcher LE, Prahalad V, Niedernhofer LJ, Robbins PD. Targeting Cellular Senescence with Senotherapeutics: Senolytics and Senomorphics. FEBS J. 2022 Jan 11. doi: 10.1111/febs.16350. Epub ahead of print. PMID: 35015337.
2021
Simon, M., Yang, J., Gigas, J., Schaff, T. M., Yu, S. L., Zhang, L., Zagorulya, M., Tombline, G., Gilbert, M., Pope, A., Van Meter, M., Emmrich, S., Han, J., Ryu, S, Tare, A., Zhu, Y., Hudgins, A., Atzmon, G., Barzilai, N., Wolfe, A., Moody, K., Garcia, B., Thomas, D. D., Robbins, P. D., Vijg, J., Seluanov, A., Suh, Y. and Gorbunova, V. (2021) A rare variant of SIRT6 identified in human centenarians improves genome maintenance and shows stronger interaction with Lamin A. bioRxiv 2021.12.13.472381; doi: https://doi.org/10.1101/2021.12.13.472381
Saul, D., Kosinsky, R. L., Atkinson, E. J., Doolittle, M. L., LeBrasseur, N. K., Pignolo, R., Robbins, P. D., Niedernhofer, L. J., Ikeno, Y., Passos, J., Monroe, D. G., Tchkonia, T., Kirkland, J. L., Farr, J. N. and Khosla, S. A New Gene Set Identifies Senescent Cells and Predicts Senescence-Associated Pathways Across Tissues. BioRxiv doi: https://doi.org/10.1101/2021.12.10.472095
Verdoorn BP, Evans TK, Hanson GJ, Zhu Y, Langhi Prata LGP, Pignolo RJ, Atkinson EJ, Wissler-Gerdes EO, Kuchel GA, Mannick JB, Kritchevsky SB, Khosla S, Rizza SA, Walston JD, Musi N, Lipsitz LA, Kiel DP, Yung R, LeBrasseur NK, Singh RJ, McCarthy T, Puskarich MA, Niedernhofer LJ, Robbins PD, Sorenson M, Tchkonia T, Kirkland JL. Fisetin for COVID-19 in skilled nursing facilities: Senolytic trials in the COVID era. J Am Geriatr Soc. 2021 Nov;69(11):3023-3033. doi: 10.1111/jgs.17416. Epub 2021 Aug 20. PMID: 34375437; PMCID: PMC8447437
Zhang L, Zhao J, Mu X, McGowan SJ, Angelini L, O'Kelly RD, Yousefzadeh MJ, Sakamoto A, Aversa Z, LeBrasseur NK, Suh Y, Huard J, Kamenecka TM, Niedernhofer LJ, Robbins PD. Novel small molecule inhibition of IKK/NF-κB activation reduces markers of senescence and improves healthspan in mouse models of aging. Aging Cell. 2021 Nov 3:e13486. doi: 10.1111/acel.13486. Epub ahead of print. PMID: 34734460.
Zhang L, Pitcher LE, Prahalad V, Niedernhofer LJ, Robbins PD. Recent advances in the discovery of senolytics. Mech Ageing Dev. 2021 Oct 14;200:111587. doi: 10.1016/j.mad.2021.111587. Epub ahead of print. PMID: 34656616.
Narasimhan A, Flores RR, Robbins PD, Niedernhofer LJ. Role of Cellular Senescence in Type II Diabetes. Endocrinology. 2021 Oct 1;162(10):bqab136. doi: 10.1210/endocr/bqab136. PMID: 34363464; PMCID: PMC8386762.
Tripathi U, Nchioua R, Prata LGPL, Zhu Y, Gerdes EOW, Giorgadze N, Pirtskhalava T, Parker E, Xue A, Espindola-Netto JM, Stenger S, Robbins PD, Niedernhofer LJ, Dickinson SL, Allison DB, Kirchhoff F, Sparrer KMJ, Tchkonia T, Kirkland JL. SARS-CoV-2 causes senescence in human cells and exacerbates the senescence-associated secretory phenotype through TLR-3. Aging (Albany NY). 2021 Sep 16;13(18):21838-21854. doi: 10.18632/aging.203560. Epub 2021 Sep 16. PMID: 34531331; PMCID: PMC8507266.
Lin, J. R., Sin-Chan, P., Mitra, J., Zhang, Q., Reza Jabalameli, M., Wang, Z., Nguyen, N., Gao, T., Holtzer, R., Ye, K., Shuldiner, A., Gorbunova, V., Ladiges, W. C., Niedernhofer, L. J., Robbins, P. D., Milman, S., Suh, Y., Vijg, J., Barzilai, N. and Z. D. Zhang. Rare coding variants in conserved aging pathways contribute to human longevity and protection against AD and other age-related diseases. Nature Aging, in press
Evans CH, Ghivizzani SC, Robbins PD. Orthopaedic Gene Therapy: Twenty-Five Years On. JBJS Rev. 2021 Aug 26;9(8):10.2106/JBJS.RVW.20.00220. doi: 10.2106/JBJS.RVW.20.00220. PMID: 34437305; PMCID: PMC8654240.
Ryu S, Han J, Norden-Krichmar TM, Zhang Q, Lee S, Zhang Z, Atzmon G, Niedernhofer LJ, Robbins PD, Barzilai N, Schork NJ, Suh Y. Genetic signature of human longevity in PKC and NF-κB signaling. Aging Cell. 2021 Jul;20(7):e13362. doi: 10.1111/acel.13362. Epub 2021 Jul 1. PMID: 34197020; PMCID: PMC8282271.
Camell CD, Yousefzadeh MJ, Zhu Y, Langhi Prata LGP, Huggins MA, Pierson M, Zhang L, O'Kelly RD, Pirtskhalava T, Xun P, Ejima K, Xue A, Tripathi U, Machado Espindola-Netto J, Giorgadze N, Atkinson EJ, Inman CL, Johnson KO, Cholensky SH, Carlson TW, LeBrasseur NK, Khosla S, O'Sullivan MG, Allison DB, Jameson SC, Meves A, Li M, Prakash YS, Chiarella SE, Hamilton SE, Tchkonia T, Niedernhofer LJ, Kirkland JL, Robbins PD. Senolytics reduce coronavirus-related mortality in old mice. Science. 2021 Jun 8:eabe4832. doi: 10.1126/science.abe4832. Epub ahead of print. PMID: 34103349.
Yousefzadeh MJ, Flores RR, Zhu Y, Schmiechen ZC, Brooks RW, Trussoni CE, Cui Y, Angelini L, Lee KA, McGowan SJ, Burrack AL, Wang D, Dong Q, Lu A, Sano T, O'Kelly RD, McGuckian CA, Kato JI, Bank MP, Wade EA, Pillai SPS, Klug J, Ladiges WC, Burd CE, Lewis SE, LaRusso NF, Vo NV, Wang Y, Kelley EE, Huard J, Stromnes IM, Robbins PD, Niedernhofer LJ. An aged immune system drives senescence and ageing of solid organs. Nature. 2021 May 12. doi: 10.1038/s41586-021-03547-7. Epub ahead of print. PMID: 33981041.
Pitcher LE, Wong AK, Robbins PD. Targeting ATM to mitigate intervertebral disc degeneration. Aging (Albany NY). 2021 Apr 22;13(8):10814-10815. doi: 10.18632/aging.203015. Epub 2021 Apr 22. PMID: 33902007; PMCID: PMC8109090.
Dorronsoro A, Santiago FE, Grassi D, Zhang T, Lai RC, McGowan SJ, Angelini L, Lavasani M, Corbo L, Lu A, Brooks RW, Garcia-Contreras M, Stolz DB, Amelio A, Boregowda SV, Fallahi M, Reich A, Ricordi C, Phinney DG, Huard J, Lim SK, Niedernhofer LJ, Robbins PD. Mesenchymal stem cell-derived extracellular vesicles reduce senescence and extend health span in mouse models of aging. Aging Cell. 2021 Apr;20(4):e13337. doi: 10.1111/acel.13337. Epub 2021 Mar 16. PMID: 33728821; PMCID: PMC8045949.
Lee KA, Robbins PD, Camell CD. Intersection of immunometabolism and immunosenescence during aging. Curr Opin Pharmacol. 2021 Mar 5;57:107-116. doi: 10.1016/j.coph.2021.01.003. Epub ahead of print. PMID: 33684669.
Yousefzadeh M, Henpita C, Vyas R, Soto-Palma C, Robbins P, Niedernhofer L. DNA damage-how and why we age? Elife. 2021 Jan 29;10:e62852. doi: 10.7554/eLife.62852. PMID: 33512317.
Saccon TD, Nagpal R, Yadav H, Cavalcante MB, Nunes ADC, Schneider A, Gesing A, Hughes B, Yousefzadeh M, Tchkonia T, Kirkland JL, Niedernhofer LJ, Robbins PD, Masternak MM. Senolytic combination of Dasatinib and Quercetin alleviates intestinal senescence and inflammation and modulates the gut microbiome in aged mice. J Gerontol A Biol Sci Med Sci. 2021 Jan 6:glab002. doi: 10.1093/gerona/glab002. Epub ahead of print. PMID: 33406219.
2020
Wong A, Kieu T, Robbins PD. The Ercc1-/Δ mouse model of accelerated senescence and aging for identification and testing of novel senotherapeutic interventions. Aging (Albany NY). 2020 Dec 22;12(24):24481-24483. doi: 10.18632/aging.202321. Epub 2020 Dec 22. PMID: 33353886; PMCID: PMC7803498.
Noren Hooten N, Yáñez-Mó M, DeRita R, Russell A, Quesenberry P, Ramratnam B, Robbins PD, Di Vizio D, Wen S, Witwer KW, Languino LR. Hitting the Bullseye: Are extracellular vesicles on target? J Extracell Vesicles. 2020 Nov;10(1):e12032. doi: 10.1002/jev2.12032. Epub 2020 Nov 29. PMID: 33708359; PMCID: PMC7890543.
Robbins PD, Jurk D, Khosla S, Kirkland JL, LeBrasseur NK, Miller JD, Passos JF, Pignolo RJ, Tchkonia T, Niedernhofer LJ. Senolytic Drugs: Reducing Senescent Cell Viability to Extend Health Span. Annu Rev Pharmacol Toxicol. 2020 Sep 30. doi: 10.1146/annurev-pharmtox-050120-105018. Epub ahead of print. PMID: 32997601.
Mu X, Tseng C, Hambright WS, Matre P, Lin CY, Chanda P, Chen W, Gu J, Ravuri S, Cui Y, Zhong L, Cooke JP, Niedernhofer LJ, Robbins PD, Huard J. Cytoskeleton stiffness regulates cellular senescence and innate immune response in Hutchinson-Gilford Progeria Syndrome. Aging Cell. 2020 Aug;19(8):e13152. doi: 10.1111/acel.13152. Epub 2020 Jul 25. PMID: 32710480; PMCID: PMC7431831.
Zhang ZD, Milman S, Lin JR, Wierbowski S, Yu H, Barzilai N, Gorbunova V, Ladiges WC, Niedernhofer LJ, Suh Y, Robbins PD, Vijg J. Genetics of extreme human longevity to guide drug discovery for healthy ageing. Nat Metab. 2020 Aug;2(8):663-672. doi: 10.1038/s42255-020-0247-0. Epub 2020 Jul 27. PMID: 32719537.
Han Y, Zhou CM, Shen H, Tan J, Dong Q, Zhang L, McGowan SJ, Zhao J, Sowa GA, Kang JD, Niedernhofer LJ, Robbins PD, Vo NN. Attenuation of ataxia telangiectasia mutated signalling mitigates age-associated intervertebral disc degeneration. Aging Cell. 2020 Jul;19(7):e13162. doi: 10.1111/acel.13162. Epub 2020 Jun 21. PMID: 32567210; PMCID: PMC7406969.
Yousefzadeh MJ, Wilkinson JE, Hughes B, Gadela N, Ladiges WC, Vo N, Niedernhofer LJ, Huffman DM, Robbins PD. Heterochronic parabiosis regulates the extent of cellular senescence in multiple tissues. Geroscience. 2020 Jun;42(3):951-961. doi: 10.1007/s11357-020-00185-1. Epub 2020 Apr 13. PMID: 32285290; PMCID: PMC7286998.
Lei C, Colangelo D, Patil P, Li V, Ngo K, Wang D, Dong Q, Yousefzadeh MJ, Lin H, Lee J, Kang J, Sowa G, Wyss-Coray T, Niedernhofer LJ, Robbins PD, Huffman DM, Vo N. Influences of circulatory factors on intervertebral disc aging phenotype. Aging (Albany NY). 2020 Jun 11;12(12):12285-12304. doi: 10.18632/aging.103421. Epub 2020 Jun 11. PMID: 32527988; PMCID: PMC7343497.
Zhao J, Zhang L, Lu A, Han Y, Colangelo D, Bukata C, Scibetta A, Yousefzadeh MJ, Li X, Gurkar AU, McGowan SJ, Angelini L, O'Kelly R, Li H, Corbo L, Sano T, Nick H, Pola E, Pilla SPS, Ladiges WC, Vo N, Huard J, Niedernhofer LJ, Robbins PD. ATM is a key driver of NF-κB-dependent DNA-damage-induced senescence, stem cell dysfunction and aging. Aging (Albany NY). 2020 Mar 22;12(6):4688-4710. doi: 10.18632/aging.102863. Epub 2020 Mar 22. PMID: 32201398; PMCID: PMC7138542.
Yousefzadeh MJ, Zhao J, Bukata C, Wade EA, McGowan SJ, Angelini LA, Bank MP, Gurkar AU, McGuckian CA, Calubag MF, Kato JI, Burd CE, Robbins PD, Niedernhofer LJ. Tissue specificity of senescent cell accumulation during physiologic and accelerated aging of mice. Aging Cell. 2020 Mar;19(3):e13094. doi: 10.1111/acel.13094. Epub 2020 Jan 25. PMID: 31981461; PMCID: PMC7059165.
Grange C, Papadimitriou E, Dimuccio V, Pastorino C, Molina J, O'Kelly R, Niedernhofer LJ, Robbins PD, Camussi G, Bussolati B. Urinary Extracellular Vesicles Carrying Klotho Improve the Recovery of Renal Function in an Acute Tubular Injury Model. Mol Ther. 2020 Feb 5;28(2):490-502. doi: 10.1016/j.ymthe.2019.11.013. Epub 2019 Nov 18. PMID: 31818691; PMCID: PMC7000999.
2019
Gorgoulis V, Adams PD, Alimonti A, Bennett DC, Bischof O, Bishop C, Campisi J, Collado M, Evangelou K, Ferbeyre G, Gil J, Hara E, Krizhanovsky V, Jurk D, Maier AB, Narita M, Niedernhofer L, Passos JF, Robbins PD, Schmitt CA, Sedivy J, Vougas K, von Zglinicki T, Zhou D, Serrano M, Demaria M. Cellular Senescence: Defining a Path Forward. Cell. 2019 Oct 31;179(4):813-827. doi: 10.1016/j.cell.2019.10.005. PMID: 31675495.
Newman JC, Sokoloski JL, Robbins PD, Niedernhofer LJ, Reed MJ, Wei J, Austad SN, Barzilai N, Cohen HJ, Kuchel GA, Kirkland JL, Pignolo RJ. Creating the Next Generation of Translational Geroscientists. J Am Geriatr Soc. 2019 Sep;67(9):1934-1939. doi: 10.1111/jgs.16055. Epub 2019 Jul 9. PMID: 31287934; PMCID: PMC6771814.
Flores RR, Carbo L, Kim E, Van Meter M, De Padilla CML, Zhao J, Colangelo D, Yousefzadeh MJ, Angelini LA, Zhang L, Pola E, Vo N, Evans CH, Gambotto A, Niedernhofer LJ, Robbins PD. Adenoviral gene transfer of a single-chain IL-23 induces psoriatic arthritis-like symptoms in NOD mice. FASEB J. 2019 Aug;33(8):9505-9515. doi: 10.1096/fj.201900420R. Epub 2019 Jun 6. PMID: 31170010; PMCID: PMC6662986.
Hambright WS, Niedernhofer LJ, Huard J, Robbins PD. Murine models of accelerated aging and musculoskeletal disease. Bone. 2019 Aug;125:122-127. doi: 10.1016/j.bone.2019.03.002. Epub 2019 Mar 4. PMID: 30844492.
Nogueira-Recalde U, Lorenzo-Gómez I, Blanco FJ, Loza MI, Grassi D, Shirinsky V, Shirinsky I, Lotz M, Robbins PD, Domínguez E, Caramés B. Fibrates as drugs with senolytic and autophagic activity for osteoarthritis therapy. EBioMedicine. 2019 Jul;45:588-605. doi: 10.1016/j.ebiom.2019.06.049. Epub 2019 Jul 5. PMID: 31285188; PMCID: PMC6642320.
Fuhrmann-Stroissnigg H, Santiago FE, Grassi D, Ling Y, Niedernhofer LJ, Robbins PD. SA-β-Galactosidase-Based Screening Assay for the Identification of Senotherapeutic Drugs. J Vis Exp. 2019 Jun 28;(148). doi: 10.3791/58133. PMID: 31305507.
Yousefzadeh MJ, Melos KI, Angelini L, Burd CE, Robbins PD, Niedernhofer LJ. Mouse Models of Accelerated Cellular Senescence. Methods Mol Biol. 2019;1896:203-230. doi: 10.1007/978-1-4939-8931-7_17. PMID: 30474850.
Zhang L, Yousefzadeh MJ, Suh Y, Niedernhofer LJ, Robbins PD. Signal Transduction, Ageing and Disease. Subcell Biochem. 2019;91:227-247. doi: 10.1007/978-981-13-3681-2_9. PMID: 30888655.
Patil P, Dong Q, Wang D, Chang J, Wiley C, Demaria M, Lee J, Kang J, Niedernhofer LJ, Robbins PD, Sowa G, Campisi J, Zhou D, Vo N. Systemic clearance of p16INK4a -positive senescent cells mitigates age-associated intervertebral disc degeneration. Aging Cell. 2019 Jun;18(3):e12927. doi: 10.1111/acel.12927. Epub 2019 Mar 21. PMID: 30900385; PMCID: PMC6516165.
Patil P, Falabella M, Saeed A, Lee D, Kaufman B, Shiva S, Croix CS, Van Houten B, Niedernhofer LJ, Robbins PD, Lee J, Gwendolyn S, Vo NV. Oxidative stress-induced senescence markedly increases disc cell bioenergetics. Mech Ageing Dev. 2019 Jun;180:97-106. doi: 10.1016/j.mad.2019.04.006. Epub 2019 Apr 17. PMID: 31002926.
Kawakami Y, Hambright WS, Takayama K, Mu X, Lu A, Cummins JH, Matsumoto T, Yurube T, Kuroda R, Kurosaka M, Fu FH, Robbins PD, Niedernhofer LJ, Huard J. Rapamycin Rescues Age-Related Changes in Muscle-Derived Stem/Progenitor Cells from Progeroid Mice. Mol Ther Methods Clin Dev. 2019 May 30;14:64-76. doi: 10.1016/j.omtm.2019.05.011. PMID: 31312666; PMCID: PMC6610712.
Lefèvre S, Knedla A, Tennie C, Kampmann A, Wunrau C, Dinser R, Korb A, Schnäker EM, Tarner IH, Robbins PD, Evans CH, Stürz H, Steinmeyer J, Gay S, Schölmerich J, Pap T, Müller-Ladner U, Neumann E. Synovial fibroblasts spread rheumatoid arthritis to unaffected joints. Nat Med. 2009 Zhang L, Zhao J, Gurkar A, Niedernhofer LJ, Robbins PD. Methods to Quantify the NF-κB Pathway During Senescence. Methods Mol Biol. 2019;1896:231-250. doi: 10.1007/978-1-4939-8931-7_18. PMID: 30474851.
Bell-Temin H, Yousefzadeh MJ, Bondarenko A, Quarles E, Jones-Laughner J, Robbins PD, Ladiges W, Niedernhofer LJ, Yates NA. Measuring biological age in mice using differential mass spectrometry. Aging (Albany NY). 2019 Feb 11;11(3):1045-1061. doi: 10.18632/aging.101810. PMID: 30745468; PMCID: PMC6382423.
2018
Justice JN, Niedernhofer L, Robbins PD, Aroda VR, Espeland MA, Kritchevsky SB, Kuchel GA, Barzilai N. Development of Clinical Trials to Extend Healthy Lifespan. Cardiovasc Endocrinol Metab. 2018 Dec;7(4):80-83. doi: 10.1097/XCE.0000000000000159. PMID: 30906924; PMCID: PMC6428447.
Patil P, Niedernhofer LJ, Robbins PD, Lee J, Sowa G, Vo N. Cellular senescence in intervertebral disc aging and degeneration. Curr Mol Biol Rep. 2018 Dec;4(4):180-190. doi: 10.1007/s40610-018-0108-8. Epub 2018 Oct 25. PMID: 30473991; PMCID: PMC6248341.
Théry C, Witwer KW, Aikawa E, Alcaraz MJ, Anderson JD, Andriantsitohaina R, Antoniou A, Arab T, Archer F, Atkin-Smith GK, Ayre DC, Bach JM, Bachurski D, Baharvand H, Balaj L, Baldacchino S, Bauer NN, Baxter AA, Bebawy M, Beckham C, Bedina Zavec A, Benmoussa A, Berardi AC, Bergese P, Bielska E, Blenkiron C, Bobis-Wozowicz S, Boilard E, Boireau W, Bongiovanni A, Borràs FE, Bosch S, Boulanger CM, Breakefield X, Breglio AM, Brennan MÁ, Brigstock DR, Brisson A, Broekman ML, Bromberg JF, Bryl-Górecka P, Buch S, Buck AH, Burger D, Busatto S, Buschmann D, Bussolati B, Buzás EI, Byrd JB, Camussi G, Carter DR, Caruso S, Chamley LW, Chang YT, Chen C, Chen S, Cheng L, Chin AR, Clayton A, Clerici SP, Cocks A, Cocucci E, Coffey RJ, Cordeiro-da-Silva A, Couch Y, Coumans FA, Coyle B, Crescitelli R, Criado MF, D'Souza-Schorey C, Das S, Datta Chaudhuri A, de Candia P, De Santana EF, De Wever O, Del Portillo HA, Demaret T, Deville S, Devitt A, Dhondt B, Di Vizio D, Dieterich LC, Dolo V, Dominguez Rubio AP, Dominici M, Dourado MR, Driedonks TA, Duarte FV, Duncan HM, Eichenberger RM, Ekström K, El Andaloussi S, Elie-Caille C, Erdbrügger U, Falcón-Pérez JM, Fatima F, Fish JE, Flores-Bellver M, Försönits A, Frelet-Barrand A, Fricke F, Fuhrmann G, Gabrielsson S, Gámez-Valero A, Gardiner C, Gärtner K, Gaudin R, Gho YS, Giebel B, Gilbert C, Gimona M, Giusti I, Goberdhan DC, Görgens A, Gorski SM, Greening DW, Gross JC, Gualerzi A, Gupta GN, Gustafson D, Handberg A, Haraszti RA, Harrison P, Hegyesi H, Hendrix A, Hill AF, Hochberg FH, Hoffmann KF, Holder B, Holthofer H, Hosseinkhani B, Hu G, Huang Y, Huber V, Hunt S, Ibrahim AG, Ikezu T, Inal JM, Isin M, Ivanova A, Jackson HK, Jacobsen S, Jay SM, Jayachandran M, Jenster G, Jiang L, Johnson SM, Jones JC, Jong A, Jovanovic-Talisman T, Jung S, Kalluri R, Kano SI, Kaur S, Kawamura Y, Keller ET, Khamari D, Khomyakova E, Khvorova A, Kierulf P, Kim KP, Kislinger T, Klingeborn M, Klinke DJ 2nd, Kornek M, Kosanović MM, Kovács ÁF, Krämer-Albers EM, Krasemann S, Krause M, Kurochkin IV, Kusuma GD, Kuypers S, Laitinen S, Langevin SM, Languino LR, Lannigan J, Lässer C, Laurent LC, Lavieu G, Lázaro-Ibáñez E, Le Lay S, Lee MS, Lee YXF, Lemos DS, Lenassi M, Leszczynska A, Li IT, Liao K, Libregts SF, Ligeti E, Lim R, Lim SK, Linē A, Linnemannstöns K, Llorente A, Lombard CA, Lorenowicz MJ, Lörincz ÁM, Lötvall J, Lovett J, Lowry MC, Loyer X, Lu Q, Lukomska B, Lunavat TR, Maas SL, Malhi H, Marcilla A, Mariani J, Mariscal J, Martens-Uzunova ES, Martin-Jaular L, Martinez MC, Martins VR, Mathieu M, Mathivanan S, Maugeri M, McGinnis LK, McVey MJ, Meckes DG Jr, Meehan KL, Mertens I, Minciacchi VR, Möller A, Møller Jørgensen M, Morales-Kastresana A, Morhayim J, Mullier F, Muraca M, Musante L, Mussack V, Muth DC, Myburgh KH, Najrana T, Nawaz M, Nazarenko I, Nejsum P, Neri C, Neri T, Nieuwland R, Nimrichter L, Nolan JP, Nolte-'t Hoen EN, Noren Hooten N, O'Driscoll L, O'Grady T, O'Loghlen A, Ochiya T, Olivier M, Ortiz A, Ortiz LA, Osteikoetxea X, Østergaard O, Ostrowski M, Park J, Pegtel DM, Peinado H, Perut F, Pfaffl MW, Phinney DG, Pieters BC, Pink RC, Pisetsky DS, Pogge von Strandmann E, Polakovicova I, Poon IK, Powell BH, Prada I, Pulliam L, Quesenberry P, Radeghieri A, Raffai RL, Raimondo S, Rak J, Ramirez MI, Raposo G, Rayyan MS, Regev-Rudzki N, Ricklefs FL, Robbins PD, Roberts DD, Rodrigues SC, Rohde E, Rome S, Rouschop KM, Rughetti A, Russell AE, Saá P, Sahoo S, Salas-Huenuleo E, Sánchez C, Saugstad JA, Saul MJ, Schiffelers RM, Schneider R, Schøyen TH, Scott A, Shahaj E, Sharma S, Shatnyeva O, Shekari F, Shelke GV, Shetty AK, Shiba K, Siljander PR, Silva AM, Skowronek A, Snyder OL 2nd, Soares RP, Sódar BW, Soekmadji C, Sotillo J, Stahl PD, Stoorvogel W, Stott SL, Strasser EF, Swift S, Tahara H, Tewari M, Timms K, Tiwari S, Tixeira R, Tkach M, Toh WS, Tomasini R, Torrecilhas AC, Tosar JP, Toxavidis V, Urbanelli L, Vader P, van Balkom BW, van der Grein SG, Van Deun J, van Herwijnen MJ, Van Keuren-Jensen K, van Niel G, van Royen ME, van Wijnen AJ, Vasconcelos MH, Vechetti IJ Jr, Veit TD, Vella LJ, Velot É, Verweij FJ, Vestad B, Viñas JL, Visnovitz T, Vukman KV, Wahlgren J, Watson DC, Wauben MH, Weaver A, Webber JP, Weber V, Wehman AM, Weiss DJ, Welsh JA, Wendt S, Wheelock AM, Wiener Z, Witte L, Wolfram J, Xagorari A, Xander P, Xu J, Yan X, Yáñez-Mó M, Yin H, Yuana Y, Zappulli V, Zarubova J, Žėkas V, Zhang JY, Zhao Z, Zheng L, Zheutlin AR, Zickler AM, Zimmermann P, Zivkovic AM, Zocco D, Zuba-Surma EK. Minimal information for studies of extracellular vesicles 2018 (MISEV2018): a position statement of the International Society for Extracellular Vesicles and update of the MISEV2014 guidelines. J Extracell Vesicles. 2018 Nov 23;7(1):1535750. doi: 10.1080/20013078.2018.1535750. PMID: 30637094; PMCID: PMC6322352.
Yousefzadeh MJ, Zhu Y, McGowan SJ, Angelini L, Fuhrmann-Stroissnigg H, Xu M, Ling YY, Melos KI, Pirtskhalava T, Inman CL, McGuckian C, Wade EA, Kato JI, Grassi D, Wentworth M, Burd CE, Arriaga EA, Ladiges WL, Tchkonia T, Kirkland JL, Robbins PD, Niedernhofer LJ. Fisetin is a senotherapeutic that extends health and lifespan. EBioMedicine. 2018 Oct;36:18-28. doi: 10.1016/j.ebiom.2018.09.015. Epub 2018 Sep 29. PMID: 30279143; PMCID: PMC6197652.
Gurkar AU, Robinson AR, Cui Y, Li X, Allani SK, Webster A, Muravia M, Fallahi M, Weissbach H, Robbins PD, Wang Y, Kelley EE, Croix CMS, Niedernhofer LJ, Gill MS. Dysregulation of DAF-16/FOXO3A-mediated stress responses accelerates oxidative DNA damage induced aging. Redox Biol. 2018 Sep;18:191-199. doi: 10.1016/j.redox.2018.06.005. Epub 2018 Jun 19. PMID: 30031267; PMCID: PMC6076207.
Xu M, Pirtskhalava T, Farr JN, Weigand BM, Palmer AK, Weivoda MM, Inman CL, Ogrodnik MB, Hachfeld CM, Fraser DG, Onken JL, Johnson KO, Verzosa GC, Langhi LGP, Weigl M, Giorgadze N, LeBrasseur NK, Miller JD, Jurk D, Singh RJ, Allison DB, Ejima K, Hubbard GB, Ikeno Y, Cubro H, Garovic VD, Hou X, Weroha SJ, Robbins PD, Niedernhofer LJ, Khosla S, Tchkonia T, Kirkland JL. Senolytics improve physical function and increase lifespan in old age. Nat Med. 2018 Aug;24(8):1246-1256. doi: 10.1038/s41591-018-0092-9. Epub 2018 Jul 9. PMID: 29988130; PMCID: PMC6082705.
Fuhrmann-Stroissnigg H, Niedernhofer LJ, Robbins PD. Hsp90 inhibitors as senolytic drugs to extend healthy aging. Cell Cycle. 2018;17(9):1048-1055. doi: 10.1080/15384101.2018.1475828. Epub 2018 Jul 23. PMID: 29886783; PMCID: PMC6110594.
Robinson AR, Yousefzadeh MJ, Rozgaja TA, Wang J, Li X, Tilstra JS, Feldman CH, Gregg SQ, Johnson CH, Skoda EM, Frantz MC, Bell-Temin H, Pope-Varsalona H, Gurkar AU, Nasto LA, Robinson RAS, Fuhrmann-Stroissnigg H, Czerwinska J, McGowan SJ, Cantu-Medellin N, Harris JB, Maniar S, Ross MA, Trussoni CE, LaRusso NF, Cifuentes-Pagano E, Pagano PJ, Tudek B, Vo NV, Rigatti LH, Opresko PL, Stolz DB, Watkins SC, Burd CE, Croix CMS, Siuzdak G, Yates NA, Robbins PD, Wang Y, Wipf P, Kelley EE, Niedernhofer LJ. Spontaneous DNA damage to the nuclear genome promotes senescence, redox imbalance and aging. Redox Biol. 2018 Jul;17:259-273. doi: 10.1016/j.redox.2018.04.007. Epub 2018 Apr 13. PMID: 29747066; PMCID: PMC6006678.
Evans CH, Ghivizzani SC, Robbins PD. Arthritis gene therapy is becoming a reality. Nat Rev Rheumatol. 2018 Jul;14(7):381-382. doi: 10.1038/s41584-018-0009-5. PMID: 29743627.
Niedernhofer LJ, Gurkar AU, Wang Y, Vijg J, Hoeijmakers JHJ, Robbins PD. Nuclear Genomic Instability and Aging. Annu Rev Biochem. 2018 Jun 20;87:295-322. doi: 10.1146/annurev-biochem-062917-012239. PMID: 29925262.
Zhao J, Zhang L, Mu X, Doebelin C, Nguyen W, Wallace C, Reay DP, McGowan SJ, Corbo L, Clemens PR, Wilson GM, Watkins SC, Solt LA, Cameron MD, Huard J, Niedernhofer LJ, Kamenecka TM, Robbins PD. Development of novel NEMO-binding domain mimetics for inhibiting IKK/NF-κB activation. PLoS Biol. 2018 Jun 11;16(6):e2004663. doi: 10.1371/journal.pbio.2004663. PMID: 29889904; PMCID: PMC6013238.
Niedernhofer LJ, Robbins PD. Senotherapeutics for healthy ageing. Nat Rev Drug Discov. 2018 May;17(5):377. doi: 10.1038/nrd.2018.44. Epub 2018 Apr 13. PMID: 29651106.
Brooks RW, Robbins PD. Treating Age-Related Diseases with Somatic Stem Cells. Adv Exp Med Biol. 2018;1056:29-45. doi: 10.1007/978-3-319-74470-4_3. PMID: 29754173.
Yousefzadeh MJ, Schafer MJ, Noren Hooten N, Atkinson EJ, Evans MK, Baker DJ, Quarles EK, Robbins PD, Ladiges WC, LeBrasseur NK, Niedernhofer LJ. Circulating levels of monocyte chemoattractant protein-1 as a potential measure of biological age in mice and frailty in humans. Aging Cell. 2018 Apr;17(2):e12706. doi: 10.1111/acel.12706. Epub 2017 Dec 31. PMID: 29290100; PMCID: PMC5847863.
Evans CH, Ghivizzani SC, Robbins PD. Gene Delivery to Joints by Intra-Articular Injection. Hum Gene Ther. 2018 Jan;29(1):2-14. doi: 10.1089/hum.2017.181. PMID: 29160173; PMCID: PMC5773261.
Evans CH, Ghivizzani SC, Robbins PD. Arthritis Gene Therapy Approved in Korea. J Am Acad Orthop Surg. 2018 Jan 15;26(2):e36-e38. doi: 10.5435/JAAOS-D-17-00695. PMID: 29303924.