Louise is interested in understanding epigenetic mechanisms of cellular rejuvenation, aging and cellular senescence. Her work focuses on identifying epigenetic modulating therapeutics using multi-OMIC strategies. She aims to characterize the heterogeneity of aged and senescent cell populations and to unravel epigenetic-, senotherapeutic-, and OSKM – mediated mechanisms of cellular rejuvenation to guide her drug discovery efforts. In her free time, Louise enjoys shopping, concerts, hiking, and hanging out with friends.
Representative Publications:
Zhang L, Pitcher LE, Prahalad V, Niedernhofer LJ, Robbins PD. Targeting Cellular Senescence with Senotherapeutics: Senolytics and Senomorphics. FEBS J. 2022 Jan 11. doi: 10.1111/febs.16350. Epub ahead of print. PMID: 35015337.
Zhang L, Pitcher LE, Prahalad V, Niedernhofer LJ, Robbins PD. Recent advances in the discovery of senolytics. Mech Ageing Dev. 2021 Dec;200:111587. doi: 10.1016/j.mad.2021.111587. Epub 2021 Oct 14. PMID: 34656616; PMCID: PMC8687661.
Pitcher LE, Wong AK, Robbins PD. Targeting ATM to mitigate intervertebral disc degeneration. Aging (Albany NY). 2021 Apr 22;13(8):10814-10815. doi: 10.18632/aging.203015. Epub 2021 Apr 22. PMID: 33902007; PMCID: PMC8109090.
